Reliable and configurable

Our Miniature Valves and Fluidic Systems

Recent scientific advances and innovations are helping to establish microfluidics as a key technology for the future. The precise manipulation of small amounts of fluid is playing an increasingly important role in the fields of medicine, analytics and chemistry.

Flexible system solution for microfluidics

memetis develops and manufactures ultra-compact miniature valves. Innovative actuator technology based on shape memory alloys ensures increased miniaturization of fluidic components and systems and the resulting high portability or packing density.

Today's medical and analytical devices often require dimensions where solenoid valves with solenoid coils reach their technological limits.

Press comment / Miniature valves tailor-made at the blink of an eye
Miniature valves tailor-made at the blink of an eye

Microfluidic applications require ever smaller, yet very powerful valves that take up minimal space. This applies not least to portable applications in medical devices that are placed directly on patients or even implanted. Many stationary medical or environmental analytical devices also require high-performance miniature valves with dimensions where solenoid valves with solenoid coils reach their technological limits. [More]

LABO, December 22nd, 2017

Sophisticated fluidics in highly portable format


Fluidic systems

Numerous applications demand high portability of the devices while at the same time taking specific requirements into account. This applies in particular to analytics and diagnostics, where fluidic systems are worn directly on the patient or where analysis chips must be microscopable directly in the system.

We have made it our task to meet these requirements and always supply the appropriate fluidic system. Our competence in the field of microstructure technology enables us to use our own miniature components (e.g. valves) as well as the customer-specific implementation of fluidic logics in highly portable format. A high vertical range of manufacture also enables us to manufacture quickly in-house. Requests for electrical control can also be flexibly taken into account.

Our network of competent partners enables rapid integration of other active components in the fluidics system.

PROPERTIES AT A GLANCE

Flexible system solutions for clear differentiation
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CUSTOMIZABLE DESIGN

The layered structure of memetis' miniature valves enables simple and very stable designs, which can reflect market and customer specific requirements. Complex fluidics and multi-channel valves are also part of memetis' performance spectrum.

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Silent operation

Shape memory alloys (SMA) as used for memetis' valve actuators enable silent operation. This enables application fields with increased noise sensitivity.

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BIOCOMPATIBLE & LOW FATIGUE

The materials used by memetis are biocompatible and thus also suitable for use in medical technology or biotechnology. For particularly high requirements, fatigue-free materials with significantly increased operating times (over 10 million switching cycles) can be used.

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COMPETITIVE PRODUCTION

The innovative memetis process and selected materials allow the manufacture of competitive miniature valves. memetis' valves operate efficiently and reliably and thus help to save costs.

Easy integration of active components

Processes normally performed in a laboratory can now be miniaturized on a single chip and performed at the point of care/ point of need to increase analysis and diagnostic efficiency and speed by reducing sample and reagent volumes.

Our valves and components are highly integratable and are the key to enabling the technology developed by our customers. This is especially true in medical technology and analytics, especially in biomedical sample analysis, which usually requires a complex fluidic architecture. At the interface of physics, chemistry, nanotechnology and biotechnology, memetis can revolutionize the way patients are diagnosed, monitored and treated.

Use cases and applications

Customer-specific fluidic components and systems

The flexible structure of our fluidic components as well as their easy adaptability and integrability enable a wide range of applications.
Let us discuss applications in your industry.

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Stem Cell Cultivation
Valve technology

Dolphin Fluidics develops, manufactures and markets intelligent fluidic systems that integrate smart valves and control and communication electronics. A strong field activity is represented by bio-analytics and diagnostics, where intelligent and compact fluidic systems are increasingly demanded for.

INITIAL SITUATION

The world’s population is growing, medical standards are increasing in many regions, and people strive for a long and healthy life up to high age. This is made possible by advanced medical technologies, which is to a great extend related to a growing understanding of molecular and genetic causes for certain diseases. These technologies enable highly personalized treatments, sometimes even for extremely rare diseases. This is supported by a strong trend for cultivating artificial tissues or even organoids in a lab environment and use these as a basis for drug development or surgical training.

CHALLENGE

By using cell lines (e.g. stem cells) of real patients, experiments can yield strongly personalized results without the need of putting the life and health of a human-being at risk. However, the quality of the obtained results stands and falls with the conditions under which the artificial cell cultures grow – these should be as realistic as possible. This is the motivation to design and develop a novel automated cell culture system that enables to induce specific differentiation pathways in dynamic cultures of adult stem cells isolated from patients. To make this become reality, not only a specialized cell culture chip is required, but also a powerful control unit for automated microfluidic handling – not readily available on the market.

SOLUTION

A novel cell cultivation system is developed that will enable the cultivation of stem cells and organoids in a parallelized way under highly controlled conditions. Such a system is expected to be useful for a wide range of medical and scientific applications. In fact, the integration of the technologies developed by the partners allows to cope with typical problems related to the use of devices currently on the market, such as the use of bulky and highly specific equipment and interfaces, the lack of a disposable culture element, the low parallelization of the process and the complexity of assembling the units. The use of precision miniaturized valves and a pulsation-free pump is crucial for avoiding high mechanical stress on the cell cultures which might disturb their growth. This miniaturized fluid handling system will thus enable much more gentle and realistic growth conditions than have been possible before.

Client comment / Fluidic system for stem cell cultivation

The automated cultivation system is an extremely innovative system. The integration of different technologies makes it possible to solve typical problems associated with the use of equipment currently on the market, such as the use of bulky and highly specific devices and interfaces, the absence of a disposable cultivation element, the low level of parallelization of the process and the complexity of assembling the units. The use of miniaturized precision valves and a pulsation-free pump is critical to avoid high mechanical stress on the cell cultures, which could interfere with their growth. The miniaturized fluid handling system developed in this study will thus allow much gentler and more realistic growth conditions than before.

Francesco Butera, Managing Director
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Application Specific Fluidics for Organ-on-Chip
Fluidic platforms

vasQlab offers a system to replicate organ-specific human tissue in vitro. memetis supports the development and implementation of a customized fluidic platform for the operation of the vasQchip.

Initial situation

vasQlab has set itself the goal of reducing animal experiments within the context of research by means of an innovative organ-on-chip model. This is achieved by replicating organ-specific human tissue on the vasQchip in vitro.

Challenge

The operation of the vasQchip requires a fluidic periphery which is characterized by simple and safe handling as well as stable and error-free operation. Due to different requirements and potential chip designs, an easily adaptable fluidic platform is currently required to meet these needs. However, the availability of such a platform, which can be described as viable from a technological and economic point of view, is currently not guaranteed.

Solution

memetis develops a fluidic platform on the basis of modular components, which accounts for the specific requirements of vasQlab. These can be quickly adapted with limited effort to minimize development cycles and accelerate the testing of the technology. The built-in miniature valves, with their low weight and small dimensions, ensure that the platform is portable and easy to microscope.

More use cases on YouTube

memetis YouTube Channel

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